BSc (Hons) Physics, UManchester 1987, PhD Medical Sciences UNSW 2007
Phone: +61 (0)2 9385 4707
Fax: +61 (0)2 9385 3950
E-mail: M.Bucknall@unsw.edu.au

Role & Interests

My work in the BMSF is divided between research activities, and laboratory administration. My principal research interest is investigation of protein oxidative damage during senescence and related disease states, and I have recently started a part-time PhD focusing on the putative oxidative damage biomarkers o,o'-dityrosine and 3-nitrotyrosine. High sensitivity assays are being developed to determine physiological and pathophysiological levels of this marker in models of disease and aging. A further aim of this work is the characterization of whole proteins which have undergone oxidative damage. Other research interests include quantitative applications of MALDI MS and development of a combined immunoaffinity chromatography - mass spectrometry approach to the species-specific quantification of pancreatic polypeptides. This will have clinical applications in the field of pancreas transplantation in diabetic patients