Supplier: Thermo Instruments
Commissioned: September 2006
Value (list price): $1,600,000
Funding Source: ARC LIEF (59%), UNSW (21%), Macquarie University (8.8%), Sydney University (6.9%), UTS (4.3%)
Instrument Manager: M.Raftery@unsw.edu.au
Location: Upper Campus, Wallace Wurth M307
SOP: Download PDF

Instrument Capability and Deployment

This instrument has electrospray and nanospray ion sources followed by a linear quadrupole ion trap mass spectrometer and a 7T FTICR (ultra) stage. The trap section is fully capable of independent MS/MS and selected ions can be transferred to the FTMS section for high resolution analysis or activation by either electron capture or infrared multiphoton resonance. It is deployed primarily for high sensitivity proteomics and is coupled with an LC Packings Ultimate 3000 Dual Gradient Comprehensive 2D LC System. (more ... supplier's specification ~800K pdf)

Major funding under ARC Linkage Infrastructure, Equipment and Facilities LE0668038. Investigators: A/Prof M Guilhaus, Dr Mark James Raftery, Prof Carolyn Louise Geczy, A/Prof Ricardo Cavicchioli, Prof Roland Stocker, Prof Marc R Wilkins (UNSW), Prof David Ernest James (Garvan Institute), Prof Mark Scott Baker (Macquarie University), Prof Richard Ian Christopherson, Prof Cristobal Guillermo Dos Remedios, Adj/Prof Ross Davey (University of Sydney), Dr Elizabeth Jane Harry (University of Technology Sydney). Title: "High resolution bioanalytical Fourier transform mass spectrometer combined with liquid chromatograph".

ARC LIEF Project Summary: The project aims to enable life sciences / medical research by enhancing high performance mass spectrometry (MS). Rapidly growing biomedical research involving protein identification/characterisation depends heavily on advances in mass spectrometry and associated separation methods. The outcomes will be to establish a powerful high resolution Fourier transform MS for ultimate sensitivity and selectivity to allow demanding experiments which cannot be undertaken with existing equipment. The new equipment will complement existing infrastructure and significantly extend the competitiveness and amount of research than can be supported by MS